Tuesday, November 12, 2013
Clinical Pharmacy MCQs
Clinical Pharmacy
1. What is the interaction between Penicillin and Probenecid?
a.
Absorption, Beneficial b.
Absorption, Harmful
c. Excretion,
Beneficial d.
Metabolism, Beneficial
2. Which of the following reason can cause drug-drug
interaction?
a. Drug potency b.
Consultation of several physicians
c. Patient
Non-compliance d.
All the above
3. Which of the following statements about OTC medications is
true?
a. They can be
procured without prescription
b. They can
cause drug-drug interaction
c. Only
pharmacist can avoid the drug-drug interactions by OTC
d. All the above
4. Which of the following combination has cheese reaction?
a. Pressoramines
and Yeast b.
MAO inhibitors and beef
c. MAO
inhibitors d.
Tetracyclins and Chicken
5. What type of DDI is observed between aspirin &
anticoagulants?
a. Absorption b.
Distribution
c. Metabolism d. Excretion
6. Metabolism of which of the following is increased with
alcohol?
a.
Warfarin b.
Phenytoin
c. Tolbutamide d.
All the above
7. Which of the following is an autoinducer?
a. Warfarin b.
Rifampicin
c. Aspirin d.
Phenacetin
8. What is homergic effect
a. When two
drugs belong to same chemical class are administered together
b. When two
drugs produce same effect
` c.
Both a & b
d. None of the
above
9. Which of the following drugs absorption is reduced or
delayed by antacids
a. Phenobarbital b.
Pseudoephedrine
c. Both a &
b d.
None of the above
10. Which of the following drugs absorption is increased by
antacids
a. Phenobarbital b.
Pseudoephedrine
c. Both a &
b d.
None of the above
11. Which of the following is caused on administration of Antacids
with Bisacodyl
a. GI irritation b.
Vomiting
c. Both a &
b d.
None of the above
12. By administration of, which of the following the absorption of
tetracyclines is hampered
a. Milk b.
Metal ions
c. Antacids d.
All the above
13. Compared to Tetracycline, Doxycycline is devoid of
a. Absorption
related DDI b.
Distribution related DDI
c. Metabolism
related DDI d.
Excretion related DDI
14. What is the effect of Aluminium Hydroxide gel on the
absorption of
Doxycycline /
Minocycline
a. Decreased b.
Increased
c. Largely
unaffected d.
Increased in presence of food
15. Prolonged usage of cholestyramine causes
a. Decreased
absorption of vit. A, D, E, K
b. Decreased
absorption of vit. B & C
c. Increased
absorption of vit. A, D, E, K
d. Increased
absorption of vit. B & C
16. Which of the following drugs absorption is increased by food?
a. Penicillin b.
Tetracyclines
c. Rifampicin d.
Riboflavin
17. Which of the following drugs absorption is decreased by food?
a. Penicillin b.
Tetracyclines
c. Rifampicin d.
All the above
18. Food increases the bioavailability of
a. Propranolol b.
Metaprolol
c.
Spironolactone d.
All the above
19. Propanthelin causes DDIs by
a. Delayed
gastric emptying b.
Enhanced GI emptying
c. No effect d.
Enhanced excretion
20. Phenytoin causes gingivitis because of altered absorption of
a. Vit. A b.
Vit. K
c. Folic acid d.
Thiamine
21. Kernicterus is caused by sulphonamides because of
a. Displacement
of bilirubin b.
Excretion of Phenobarbitone
c. Displacement
of Phenylbutazone d. None of the above
22. The interaction between Allopurinol and Azathioprine is related
to
a.
Absorption b.
Metabolism
c.
Excretion d.
Distribution
23. MAO inhibitors can
a. Inhibit
microsomal enzymes
b. Induce
microsomal enzymes
c. No effect on
microsomal enzymes
d. Cause no
reaction with cheese
24. Which of the following drugs toxicity is increased by
Frusemide?
a. Aspirin b.
Paracetamol
c. Ibuprofen d.
Diclofenac
25. Quinidine increases the toxicity of which of the following
drug?
a. Digoxin b.
Digitonin
c. Both a &
b d.
None of the above
26. Digoxin can be prescribed with
a. Frusemide b.
Bumetanide
c. Ethacrynic
acid d.
Triamterene
27. Lithium carbonate should not be prescribed with
a. Frusemide b.
Bumetanide
c. Ethacrynic
acid d.
All the above
28. Which of the following drugs produce Atropine like symptoms?
a. MAO I &
Amphetamine b.
MAO I & TCAs
c. MAO I &
Tyramine d.
None of the above
29. Guanethidine shows less effect in presence of
a. Amphetamine b.
TCAs
c.
Antipsychotics d.
All the above
30. Which of the following combinations show synergism?
a. Trimethoprim
& Sulphamethoxazole
b.
Ibuprofen & Paracetamol
c.
Pheniramine & Aspirin
d.
All the above
31. What are the classifications of drug interactions?
a.
Pharmacokinetic interactions b. Pharmacodynamic interactions
c. Pharmaceutic
interactions d.
All the above
32. Match the following
P. Aminophylline
I.V + 1.
Pharmacokinetic
Cephalothin sodium
Q.
Antagonism / Addition / 2.
Pharmaceutic
` Synergism
R. Absorption /
Distribution / 3.
Pharmacodynamic
Metabolism / Excretion
a.
P – 2 b. P – 1 c. P – 1 d. P – 3
Q – 3 Q – 2 Q – 3 Q – 1
R – 1 R – 3 R – 2 R – 2
33. Match the following
P. Tetracyclines 1.
Metabolism
Q. Warfarin 2.
Distribution
R. Salicylates 3.
Absorption
S. Phenobarbital 4.
Excretion
a. P – 4 b.
P – 3 c. P – 3 d. P – 1
Q – 2 Q – 2 Q – 2 Q – 2
R – 3 R – 1 R – 4 R – 3
S – 1 S – 4 S – 1 S – 4
34. Match the following
P.
Laxatives 1.
Adsorption
Q.
Antidiarrhoeals 2.
PH
R.
Antacids 3.
Microbial flora
S.
Antibiotics 4.
Motility
a. P – 4 b.
P – 3 c. P – 4 d. P – 1
Q – 2 Q – 2 Q – 1 Q – 2
R – 3 R – 1 R – 2 R – 3
S – 1 S – 4 S – 3
S – 4
35. Match the following
P. Cimetidine 1.
Penicillin
Q. Polycyclic
aromatic Hydrocarbons 2. Enzyme
inhibition
R. MAO
Inhibitors 3.
Enzyme induction
S. Probenecid 4.
Cheese reaction
a. P – 4 b.
P – 3 c.
P –2 d. P – 1
Q – 2 Q –
2 Q – 3 Q – 2
R – 3 R – 1 R – 4 R – 3
S – 1 S – 4 S – 1 S – 4
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