Short Cuts

Kreb cycle
Can an intelligent officer karan succesfully solve foreign mafia operation

citrate-aconitase-isocitrate-oxalosuccinate- ketoglutarate(alpha k.g.)-succinate-fumarate-malate-oxaloacetate

Essential Amino acids

My True love is through valentine love phrases

methionine,threonine,leucine,isoleucine,tryptophan,valine,lysine,phenylalanine


Busulfan
features ABCDEF:
Alkylating agent
Bone marrow suppression
CML indication
Dark skin (hyperpigmentation)
Endrocrine insufficiency (adrenal)
Fibrosis (pulmonary)

Drugs causing Torsades de Pointes
APACHE
Amiodarone Procainamide Arsenium Cisapride Haloperidol Eritromycin


Morphine:side-effects MORPHINE:
Myosis
Out of it (sedation)
Respiratory depression
Pneumonia (aspiration)
Hypotension
Infrequency (constipation, urinary retention)
Nausea
Emesis

Aspirin Side effects
Aspirin
Asthma
Salicyalism
Peptic ulcer disease/ Phosphorylation-oxidation uncoupling/ PPH/ Platelet disaggregation/ Premature closure of PDA
Intestinal blood loss
Reye's syndrome
Idiosyncracy
Noise (tinnitus)

SSRIs: side effects SSRI:
Serotonin syndrome
Stimulate CNS

Reproductive disfunctions in male
Insomnia

Inhalation anesthetics SHINE:
Sevoflurane
Halothane
Isoflurane
Nitrous oxide
Enflurane

Teratogenic drugs "Win TERATOgenic

Warfarin
Thalidomide
Epileptic drugs: phenytoin, valproate, carbamazepine
Retinoid
ACE inhibitor
Third element: lithium
OCP and other hormones (eg danazol)

Gynaecomastia-causing drugs
DISCOS:
Digoxin
Isoniazid
Spironolactone
Cimetidine
Oestrogens
Stilboestrol

Methyldopa Side effects
METHYLDOPA:
Mental retardation
Electrolyte imbalance
Tolerance
Headache/ Hepatotoxicity psYcological upset
Lactation in female
Dry mouth
Oedema
Parkinsonism
Anaemia (haemolytic)

Antirheumatic agents (disease modifying): members
CHAMP:
Cyclophosphamide
Hydroxycloroquine and choloroquinine
Auranofin and other gold compounds
Methotrexate
Penicillamine


Antiarrhythmics: class III members BIAS:
Bretylium
Ibutilide
Amiodarone
Sotalol

Phenytoin: adverse effects PHENYTOIN:
P-450 interactions
Hirsutism
Enlarged gums
Nystagmus
Yellow-browning of skin
Teratogenicity
Osteomalacia
Interference with B12 metabolism (hence anemia)
Neuropathies: vertigo, ataxia, and headache

Sodium Valproate side effccts
VALPROATE
Vomiting
Alopecia
Liver toxicity
Pancreatitis/ Pancytopenia
Retention of fats (weight gain)
Oedema (peripheral oedema)
Appetite increase
Tremor
Enzyme inducer (liver)

Steroids: side effects
BECLOMETHASONE:
Buffalo hump
Easy bruising
Cataracts
Larger appetite
Obesity
Moonface
Euphoria
Thin arms & legs
Hypertension/ Hyperglycaemia
Avascular necrosis of femoral head
Skin thinning
Osteoporosis
Negative nitrogen balance
Emotional liability

Vomiting: extra GI differential VOMITING:
Vestibular disturbance/ Vagal (reflex pain)
Opiates
Migrane/ Metabolic (DKA, gastroparesis, hypercalcemia)
Infections
Toxicity (cytotoxic, digitalis toxicity)
Increased ICP, Ingested alcohol
Neurogenic, psychogenic
Gestation

HMG-CoA:
Side effects:HMGCoA
Hepatotoxicity
Myositis [aka rhabdomyolysis]
• Contraindications:

Girl during pregnancy/ Growing children
• Interactions:
Coumarin/ Cyclosporine

Amiodarone: action, side effects
6 P's:
Prolongs action potential duration
Photosensitivity
Pigmentation of skin
Peripheral neuropathy
Pulmonary alveolitis and fibrosis
Peripheral conversion of T4 to T3 is inhibited -> hypothyroidism

MAOIs: indications
MAOI'S:
Melancholic [classic name for atypical depression]
Anxiety
Obesity disorders [anorexia, bulemia]
Imagined illnesses [hypochondria]
Social phobias
_ Listed in decreasing order of importance.
_ Note MAOI is inside MelAnchOlIc


Antiparkinson Drugs
SALAD
Selegiline
Anticholinenergics (trihexyphenidyl, benzhexol, ophenadrine)
L-Dopa + peripheral decarboxylase inhibitor (carbidopa, benserazide)
Amantadine
Dopamine postsynaptic receptor agonists (bromocriptine, lisuride, pergolide)

Metabolism Enzyme Inducers
Randy's Black Car Goes Putt Putt and Smokes":
Rifampin
Barbiturates
Carbamazepine
Grisoefulvin
Phenytoin
Phenobarb
Smoking cigarettes


Zero Order Kinetic Drugs
PEAZ
Phenytoin
Ethanol
Aspirin
Zero order
Someone that pees out

Therapeutic Index Formula
TILE
TI = LD / ED

PREANASTHETIC MEDICATION
HOSANA this is a christian word.
H-H2blockers
O-opeoids
S-sedatives-antianxiety
A-anticholenergic
N-neuroleptics
A-antiemetics
anti epeleptic drugs

Dr.BHAISAB's New PC.
D...deoxy barbiturates
B...barbiturates
H....hydantoin
A.. aliphatic carb acids
I....iminostilbenes
S....succinimides
B....BZD's
N.... newer drugs
P....Phenyltriazines
C... cyclic gaba analogues


Adverse effects of tetracyclins-KAPIL DEV
K kidney toxicity
A antianabolic effect
P phototoxicity
I inc ICP
L liver toxicity

D diabetes insipidus
E enamel problems
V vestibular toxicity


ADRS OF CHLORAMPHENICOL
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S.....superinfections
B.... bone marrow depression
I....irritative effects
G.....Gray baby syndrome

H...hypersensitivity

inhalational corticosteroids
Bed Bug Flew To Florida

B-BECLOMETHASONE DIPROPIONATE
B-BUDESONIDE
F-FLUTICASONE PROPIONATE
T-TRIAMCINALONE
F-FLUNISOLIDE


CAPTOPRIL Side effects CAPTOPRIL
Cough
Angioedema/ Agranulocystosis
Proteinuria/ Potassium excess
Taste changes
Orthostatic hypotension
Pregnancy contraindication/ Pancreatitis/ Pressure drop (first dose hypertension)
Renal failure (and renal artery stenosis contraindication)/ Rash
Indomethacin inhibition
Leukopenia/ Liver toxicity


Lithium: side effects
LITH:

Leukocytosis
Insipidus [diabetes insipidus, tied to polyuria]
Tremor/ Teratogenesis
Hypothyroidism

Ca++ Chennel Blocker Uses

Cererbral vasospasm / CHF
Hypertension
Angina
Suprventricular tachyarrhythmia
Migranes


MI:
signs and symptoms PULSE:

Persistent chest pains
Upset stomach
Lightheadedness
Shortness of breath
Excessive sweating


MI:
basic management BOOMAR:

Bed rest
Oxygen
Opiate
Monitor
Anticoagulate
Reduce clot size

LVF Management FOAM
Frusemide 40mg iv,
Oxygen,
Atrovent (& Ventolin) nebs,
Morphine 2.5 - 5 mg
Mitral Stenosis,

Treatment of Heart Failure: ABCDE
ACE inhibitors
Beta-blockers
Calcium channel blockers
Diuretics
Endothelin-converting enzyme inhibitors


Lines of treatment of pulmonary oedema: DOLMA

Digoxin
Oxygen
Lasix
Morfine
Aminophylline.
(Dolma is a very famous food in the middle east